Novel Origin of the 1918 Pandemic Influenza Virus Nucleoprotein Gene
نویسندگان
چکیده
منابع مشابه
Novel origin of the 1918 pandemic influenza virus nucleoprotein gene.
The nucleoprotein (NP) gene of the 1918 pandemic influenza A virus has been amplified and sequenced from archival material. The NP gene is known to be involved in many aspects of viral function and to interact with host proteins, thereby playing a role in host specificity. The 1918 NP amino acid sequence differs at only six amino acids from avian consensus sequences, consistent with reassortmen...
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1 Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 2 ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan, 3 Division of Zoonosis, Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe Un...
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BACKGROUND With a heightened increase in concern for an influenza pandemic we sought to better understand the 1918 Influenza pandemic, the most devastating epidemic of the previous century. METHODOLOGY/PRINCIPAL FINDINGS We use data from several communities in Maryland, USA as well as two ships that experienced well-documented outbreaks of influenza in 1918. Using a likelihood-based method an...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2004
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.78.22.12462-12470.2004